Endocrine Abstracts

The brain is dependent on a continuous supply of glucose as its source of energy, the rate-limiting step being the rate of transport across the blood-brain barrier. Glucose deprivation of the brain causes neuroglycopenia and rapid malfunction. This is demonstrated by the development of abnormal neurophysiological function with slowing of neural transmission and electroencephalographic changes, and by the progressive impairment of cognitive function, affecting several domains. ...